|
|
ABSTRACT
| Title |
: |
A REVIEW ON ADVANCED GLYCATION END-PRODUCTS (AGE) AND THEIR ROLE IN DIABETES MELLITUS |
| Authors |
: |
KIRTESH RAUT, SIDDHARTH AGARWAL, AAKASH PARIKH |
| Keywords |
: |
Advanced glycated end-products(AGE), Diabetes mellitus, carbonyl stress, Maillard reaction, Amadori rearrangement. |
| Issue Date |
: |
January 2015 |
| Abstract |
: |
A complex and heterogeneous group of compounds known as “Advanced Glycation End-products (AGE)” have been associated with diabetes related complications. Till date it is not known if they are the cause or consequence of the complications observed. The chemistry of AGE formation and their patho-biochemistry particularly related to the diabetic microvascular complications of nephropathy, retinopathy and neuropathy also their role in the accelerated vasculopathy observed in diabetes are discussed. Also, the concept of carbonyl stress as a cause of AGE toxicity and the alterations in the concentrations of AGE in the body, particularly in relation to diabetes and its complications such as nephropathy are also mentioned and also along with age. We have also highlighted the problems relating to current methods of AGE detection and measurement which include the lack of a universally established method of detection or unit of measurement. A review of the agents used for the treatment of advanced glycation end-products accumulation is also mentioned. |
| Page(s) |
: |
80-86 |
| ISSN |
: |
0975-9492 |
| Source |
: |
Vol. 6, No.1 |
|
Copyright to ENGG Journals Publications
