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ABSTRACT
| Title |
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Method development and validation of Vildagliptin using UV spectrophotometer |
| Authors |
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Dr. Safila Naveed, Hina Rehman, Fatima Qamar, Syeda Zainab |
| Keywords |
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Vildagliptin, accuracy, linearity, regression equation , precision. |
| Issue Date |
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October 2014 |
| Abstract |
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Vildagliptin is an antidiabetic agent, belongs to the dipeptidyl peptidase IV (DPP-4) inhibitors. The method employs measurement of absorbance at the wavelength of maximum absorptions of vildagliptin using water as a solvent. Calibration curve was linear in the concentration range of 12.5-200 microgram per ml µg/ml for vildagliptin with the correlation coefficient of 0.985. Accuracy of proposed method was confirmed by performing accuracy studies which showed the results within the range. Precision of proposed UV method was confirmed by performing intraday and inter day precision. Results were well within acceptance criteria which indicate the method has excellent scope for the determination of Vildagliptin in bulk. |
| Page(s) |
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714-717 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 5, No.10 |
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