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ABSTRACT
| Title |
: |
1,2,4-oxadiazole nucleus with versatile biological applications |
| Authors |
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Mohammad Arshad, Taqi Ahmed Khan, Meraj Alam Khan |
| Keywords |
: |
1,2,4-oxadiazole, synthesis, biological activity |
| Issue Date |
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July 2014 |
| Abstract |
: |
Azoles are the five-membered heterocyclic compounds with two or three nitrogen atoms, constitute a large group of organic substances and have been long targeted for their use as therapeutic agents. 1,2,4-oxadiazoles is a member of azole family containing two nitrogen atoms, two carbon and one oxygen atom in the ring.1,2,4-oxadiazoles have been found to possess variety of biological activities such as human tryptase inhibitory activity, antitrypanosomal activity, ß-amyloid imaging agents in Alzheimer’s disease, genotoxic activity, peptide inhibitory activity, antihyperglycemic activity, potential combretastatin A-4 (CA-4) analogs and oxadiazole mannich bases show antimyco-bacterial activity. Here in this review article we have reported the recent development in the pharmacological activity of some newly synthesized 1,2,4-oxadiazole derivatives. |
| Page(s) |
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303-316 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 5, No.7 |
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