| Abstract |
: |
An isocratic reversed phase HPLC method has been developed for determination of mefenamic acid on a Grace, alltima C18 column (250x4.6 mm) using a mobile phase consisting of methanol : ammonium acetate (pH 6) (67:33 v/v) at a flow rate of 1 mL/min. Detection was carried out at 254 nm. Retention time of mefenamic acid was 9.85 (±0.36) mins. The method was validated with respect to specificity, linearity, accuracy, precision, ruggedness, and robustness.
The proposed method is simple, precise, sensitive, and reproducible and is applicable for quantification of mefenamic acid in an Emulgel (topical formulation) developed and formulated in our laboratory. |
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