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ABSTRACT
Title |
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Formulation and In-Vitro Evaluation of Controlled Release Tablet of Bupropion Hydrochloride by Direct Compression Technique and Stability Study |
Authors |
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ANJAN PAUDEL, YOGENDRA RAJ PANDEY, SUBASH THA SHRESTHA, SUMIT CHANDRA SHRESTHA |
Keywords |
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Controlled release, Bupropion Hydrochloride, Polymers, Dissolution study, Mathematical modeling and Stability |
Issue Date |
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May 2014 |
Abstract |
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Purpose: The aim of the study was to develop and evaluate matrix based controlled drug delivery system by direct compression technique of Bupropion hydrochloride tablet and stability studies. Methods: Controlled release tablets were prepared by employing Eudragit RS 100, HPMC K15M, HPMC K100M at different concentration. Result and conclusion: All 10 batches pass friability, hardness, weight variation, assay but only three batches (CRB3D, CRB4D and CRB7D) passed the dissolution as per USP 30 NF25 for extended release tablet of Bupropion hydrochloride. All batches follow Higuchi Model followed by Pappes model. HPMC (K15M & K100M) as a matrix polymer used in tablet formulation provide a good initial retardation in the release as well as helped to enhance the overall release rate of the drug than that of Eudagit RS 100. It was observed that increase in polymer concentration retards the release of drugs in case of HPMC K15 M and HPMC K100 M. Self life of CRB7D tablet was found to be 2.37year. |
Page(s) |
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186-192 |
ISSN |
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0975-9492 |
Source |
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Vol. 5, No.5 |
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