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ABSTRACT
| Title |
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MICROSPHERIC IN-SITU GEL FOR OCULAR DRUG DELIVERY SYSTEM OF BROMFENAC SODIUM |
| Authors |
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PRERANA VENGURLEKAR, ASMITA SINGH, SUDHA RATHOD |
| Keywords |
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Bromfenac sodium (BNa), micsrospheric in-situ gelling system, egg albumin. |
| Issue Date |
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April 2014 |
| Abstract |
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Purpose: The aim of the study was to develop a sustained release microspheric in-situ gel for bromfenac sodium (BNa) to be administered through ocular route. It was prepared for the treatment of post-operative cataract surgery. It increases the therapeutic efficiency, reduces dosing frequency and prolonged duration of action. Methods: Albumin microspheres were prepared by protein gelation process and dispersed into in-situ gel, which was prepared by pH triggered method. Result and conclusion: The particle size analysis revealed that all formulations gave particles size in the range of 1-10 µm which is suitable for ocular administration of formulation. The entrapment efficiency of microspheres was found to be 84.2% and drug release from microspheres were found to be 80.558 % at 24 h. The microspheric in-situ gel of optimized formulation shows drug release of 77.989% at the end of 24 hours. Stability studies were conducted. Hence, it can be concluded that microsphere in-situ gels were a viable alternative to conventional eye drops by providing sustained release of medicaments in the eye. |
| Page(s) |
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179-185 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 5, No.4 |
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