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ABSTRACT
| Title |
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DESIGN, DEVELOPMENT AND CHARACTERIZATION OF LIPOSOMAL NEEM GEL |
| Authors |
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ASMITA SINGH, PRERANA VENGURLEKAR, SUDHA RATHOD |
| Keywords |
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Azadirachta indica, Methanolic Neem Extract (MeNE), Thin film hydration, Soya lecithin, Cholesterol, In vitro drug diffusion. |
| Issue Date |
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April 2014 |
| Abstract |
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Purpose: Liposomal formulations have been successfully used in the treatment of a number of dermatological diseases. Various synthetic as well as herbal drugs are incorporated into liposome to improve its efficacy. Incorporation of herbal extract into liposome reduces side effects which are associated with the synthetic ones. Azadirachta indica leaves possesse good anti bacterial activity, confirming the great potential of bioactive compounds of neem. Among aqueous extract and alcoholic extract, alcoholic leaf extracts of A. indica were found to be more active towards the bacterial species. Hence, this extract was incorporated into liposomes to enhance its activity in skin delivery. The objective of the present research work is to convert this age old miraculous herb into nanotechnology based formulations i.e. liposomes. An attempt has been made to prepare liposomal Neem gel for topical use for anti-microbial activity. Methods: Methanolic Neem Extract (MeNE) was incorporated into liposomes by thin film hydration method. The batch having lipid ratio i.e. Soya lecithin: Cholesterol (4:1); MeNE concentration 80 mg with entrapment efficiency 69.52 ±1.9% was finalized. Results and Conclusions: The vesicle size was found to be 3.2µm ± 0.67. In vitro drug diffusion and skin retention from liposomal gel was found to be 62.178% ± 0.91 and 20.03% ± 0.63 respectively. Stability studies indicated that formulation was stable over a period of 3 months when stored at 2-8°C. |
| Page(s) |
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140-148 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 5, No.4 |
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