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ABSTRACT
Title |
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Identification of a-Glucosidase Inhibitors From Psidium guajava Leaves and Syzygium cumini Linn. Seeds |
Authors |
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Kathirvel Alagesan*, Prabhakar Thennarasu, Vinoth Kumar, Sadasivam Sankarnarayanan, Thayumanavan Balsamy |
Keywords |
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Diabetes, a-glucosidase, Medicinal plants, P.guajava, Reversible inhibitor, S.cumini |
Issue Date |
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February 2012 |
Abstract |
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We screened for a-glucosidase inhibitors from 12 traditional medicinal plants used for the treatment of diabetes. Potent a-glucosidase inhibitory activity was found in aqueous extract of Psidium guajava leaves and Syzygium cumini Linn seed extract. Active principles inhibiting a-glucosidase were isolated and identified as apigenin 7-O-glucoside in the S.cumini Linn seed extract and Dihydro-3,3’,4’,5,7 – pentahydroxyflavone glycoside in P.guajava leaf extract through FT-IR and LC-MS. The inhibitor present in both P.guajava leaves and S.cumini Linn seed extract was found to be reversible in nature. |
Page(s) |
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316-322 |
ISSN |
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0975-9492 |
Source |
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Vol. 3, No.2 |
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