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ABSTRACT
| Title |
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FORMULATION DEVELOPMENT AND EVALUATION OF COLON TARGETED DOSAGE FORM OF IBUPROFEN |
| Authors |
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Pranjal Kumar Singh, Sanjoo Kumar, T.S.Easwari, V.K.Shukla, Guru Sharan |
| Keywords |
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Colon specific, Ibuprofen, Physiochemical parameters, Eudragit L 100. |
| Issue Date |
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January 2012 |
| Abstract |
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Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn’s disease, ulcerative colitis, irritable bowel syndrome but also for the potential it holds for the systemic delivery of proteins and therapeutic peptides. The aim of the study was to develop colon targeted film coated tablets of Ibuprofen using HPMC K4M, Eudragit L100, and Ethyl cellulose as carriers. All the formulations (F1 to F6) were evaluated for the physicochemical parameters and were subjected to in vitro drug release studies. The amount of Ibuprofen released from tablets at different time intervals was estimated by UV spectrophotometer. The formulation F6 released 98.34 % of Ibuprofen. The results of the study showed that formulation F6 is most likely to provide targeting of Ibuprofen for local action in the colon owing to its minimal release of the drug in the first 5 h. The results of the present study have demonstrated that the film coated tablet system is a promising vehicle for preventing rapid hydrolysis in gastric environment and improving oral bioavailability of Ibuprofen for the treatment of disease of colon region. |
| Page(s) |
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268-278 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 3, No.1 |
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