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ABSTRACT
| Title |
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Simultaneous Estimation of Montelukast Sodium and Fexofenadine HCL in Pharmaceutical Formulation by RP-LCPDA |
| Authors |
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Anirudha R .Chabukswar,Vishnu P. Choudhari, Swati C Jagdale, Shialesh N. Sharma, Nilesh A. Bari, Bharat D Pagare |
| Keywords |
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Montelukast and Fexofenadine HCL, Isocratic, RP-HPLC-PDA |
| Issue Date |
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January 2012 |
| Abstract |
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High resolution RP-HPLC method has been developed for the simultaneous estimation of Montelukast Sodium and Fexofenadine HCL in pharmaceutical products. Separation was achieved by using a Kromasil C18, 250 × 4.6 mm, 5 µm column with a the column temperature is 50°C, and detector wavelength is 241 nm gradient mobile phase composed of sol-A: Water, sol-B: Acetonitrile and Methanol(50:50) was used at the flow rate 1ml/min, The retention time of Montelukast sodium &, Fexofenadine HCL 3.306 & 2.214mins, respectively. The method is validated and shown to be linear. The correlation coefficients for Montelukast Sodium and Fexofenadine HCL are 0.999 and 0.999, respectively. The recovery values for Montelukast and Fexofenadine HCL ranged from 99.12–99.24% and 99.09–99.59%, respectively. The relative standard deviation for six replicates is always less than 2%. The developed method has wide applicable for the quantification of Montelukast and Fexofenadine in pharmaceutical dosage forms. |
| Page(s) |
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241-248 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 3, No.1 |
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