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ABSTRACT
| Title |
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Immunomodulatory effect of methanol extract of Solanum xanthocarpum fruits |
| Authors |
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1Rokeya Sultana, Salma Khanam, Kshama Devi |
| Keywords |
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Solanum xanthocarpum, methanol extract, Immunomodulatory activity, Cyclophosphamide, immunopotentiation |
| Issue Date |
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February 2011 |
| Abstract |
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Purpose : To study the immunomodulatory activity of methanol extracts of fruits of Solanum xanthocarpum (Solanaceae) on Swiss albino mice.
Methods
Model -Cyclophosphamide induced immunosuppression model
Animal used - Swiss albino mice.
Dose – Cyclophosphamide-30mg/kg body weight, i.p route.
Extract-100mg/kg body weight, oral route.
The extent of protection against immunosuppression caused by Cyclophosphsmide was evaluated after 14 days of drug administration, by estimating hematological parameter and neutrophil adhesion test.
Results
Methanol extracts of fruits of Solanum xanthocarpum showed pronounced immunoprotective activity by increasing the depleted levels of total WBC count and RBC, % Hb, and % neutrophils adhesion.
Conclusions
The extract was found to be effective immunomodulatory agents. |
| Page(s) |
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93-97 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 2, No.2 |
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