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ABSTRACT
| Title |
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SYNTHESIS AND EVALUATION OF ACUTE TOXICITY STUDIES AND ANALGESIC CHARACTERS OF SOME NOVEL INDOLE DERIVATIVES |
| Authors |
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Nilanjan Pahari, Dibyajyoti Saha, Vibhor K. Jain, Bindu Jain, Debajyoti Mridha |
| Keywords |
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Novel indole derivative, acute toxicity, analgesic activity, istatin. |
| Issue Date |
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October 2010 |
| Abstract |
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The present study was carried out with an objective to synthesis the novel indole derivative from istatin and to evaluate its acute toxicity studies to estimate its safety dose level and evaluate its analgesic activity. The synthesis was carried out following the scheme and all the chemicals were purified according to established method prior to use. The synthesized compound was subjected to estimation of acute toxicity studies on albino rat (swiss model). Analgesic activity was evaluated by hot plate method. The results reveal that the synthesized novel indole derivative contains Indole, Thiazolidone and Isoxazole nucleus and by the probit scale analysis the LD50 of the Novel Indole derivative was found to be 1271 mg/Kg body weight. The results of analgesic activity reveals that the compound possesses significant analgesic activity when compared to standard. |
| Page(s) |
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399-408 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 1, No.9 |
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