ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Antidiabetic activity of Rheum emodi in Alloxan induced diabetic rats.
Authors : Radhika.R, Dr.Krishnakumari, Dr.Sudarsanam.D
Keywords : R.emodi , gluconeogenic, alloxan, antidiabetic
Issue Date : September 2010
Abstract :
The present study was carried out to evaluate the antidiabetic effect of Rheum emodi rhizome extract and to study the activities of hexokinase, aldolase and phosphoglucoisomerase, and gluconeogenic enzymes such as glucose-6-phosphatase and fructose -1,6-diphosphatase in liver and kidney of normal and alloxan induced diabetic rats. Oral administration of 75 % ethanolic extract of R. emodi (250 mg/kg body weight) for 30 days, resulted in decrease in the activities of glucose-6-phosphatase, fructose-1,6-disphosphatase, aldolase and an increase in the activity of phosphoglucoisomerase and hexokinase in tissues. The study clearly shows that the R.emodi possesses antidiabetic activity.
Page(s) : 296-300
ISSN : 0975-9492
Source : Vol. 1, No.8