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ABSTRACT
| Title |
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SPECTROPHOTOMETRIC ESTIMATION OF BUSPIRONE HYDROCHLORIDE IN BULK AND ITS PHARMACEUTICAL FORMULATION |
| Authors |
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B.DHANDAPANI, S.HEMAMRUTHA, K.LAKSHMI SRAVANTHI, J.SWETHA, B.T.V.V.KAVITHA, Y.SUJITHA, D.DURGA SRINIVAS, D R.V.CELESTIN BABOO |
| Keywords |
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Uv Spectrphotometry, Colorimetry and Buspirone Hydrochloride |
| Issue Date |
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May 2010 |
| Abstract |
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Three simple, accurate, rapid and sensitive methods developed for the determination of buspirone hydrochloride in bulk drug and in its tablets by UV Spectroscopy (Method – A – Water as a Solvent), UV Spectroscopy (Method – B – Methanol as a Solvent), and Colorimetry (Method - C). In Method A buspirone hydrochloride estimated at 236 nm using distilled water as a solvent. The linearity was observed in the concentration range of 5 – 25 µg/ml with correlation co efficient of 0.9866. In Method B methanol used as a solvent. The linearity was observed in the concentration range of 10 – 50 µg/ml with correlation co efficient of 0.9905. In Method C buspirone hydrochloride is a colorless compound undergoes oxidation with 0.005M Potassium Permanganate Solution in the presence of 0.5M Sodium Hydroxide gives Pink color. The intensity of color directly proportional to the concentration of buspirone hydrochloride and its found that intensity of color stable for 20mins and the absorbance was measured at 610 nm with different time intervals with the linearity range and correlation co -efficient of 10 – 50 µg/ml and 0.9924. The result of analysis for all the methods was validated statistically and by recovery studies. |
| Page(s) |
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211-216 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 1, No.4 |
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