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ABSTRACT
| Title |
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Calcium Gluconate Mediated In Situ Gelling of Alginates for Ocular Drug Delivery. |
| Authors |
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Kenneth Reed, Mary Lankford |
| Keywords |
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Ocular, Alginate, In-Situ, Gelation, Release |
| Issue Date |
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Oct 2018 |
| Abstract |
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Purpose: Alginates form stronger gels when cross linked by divalent cations (e.g., Ca++) than when in the presence of monovalent cations (e.g., Na+). Previous work indicated that Ca++ can be displaced from calcium gluconate (CaG) by monovalent cations that are predominant in tear fluid. The purpose of this study was to determine the in situ gelling properties and drug release rates of alginate plus CaG formulations. Methods: Alginate solutions containing various concentrations of CaG were manufactured. Viscosities of the manufactured solutions were measured at ambient temperature to mimic patient storage and at eye temperature to forecast in situ gelling potential. The rates of drug release from test solutions were measured by using tryptophan as a model drug. Results: Alginate formulations were found to form stronger gels under physiological conditions when adequate amounts of CaG were added than when formulations containing only alginate were tested. Additionally, tryptophan was released more slowly when CaG was added to alginate. Alginate plus CaG formulations were found to be shear thinning, which should result in better patient acceptance. Conclusions: The inactive ingredient CaG can be used to improve the use of alginate for ocular in situ gelation. |
| Page(s) |
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165-177 |
| ISSN |
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0975-9492 |
| Source |
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Vol. 9, No.10 |
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