ISSN : 0975-9492


Open Access

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Title : Hypoglycaemic and Antioxidant Activity of SPHAG - a Poly Herbal Formulation in Alloxan Induced Wistar Albino Rats
Authors : Thamizh Selvam N, Hima KM, Sanjayakumar YR, Ranjini KR, Vasantha Kumar KG, Swamy GK
Keywords : hypoglycaemic activity, antioxidant potential, superoxide dismutase, peroxidise
Issue Date : April 2015
Abstract :
Management of Diabetes mellitus is one of the greatest challenges among the developing and developed countries. The use of herbal medicine is steadily growing in the management of various diseases all over the world. The present study has been taken up on a poly herbal formulation -SPHAG, a combination of aqueous extracts of plants Solanum nigrum, Premna corymbosa, Holarrhena pubescens, Alstonia scholaris and Gymnema sylvestre for its hypoglycaemic and antioxidant activity in alloxan induced diabetic Wistar albino rats. The four groups containing 6 animals in each group, like Healthy Control, Disease Control, SPHAG lower dose(250 mg/kg.b.wt.) and SPHAG higher dose (500 mg/kg.b.wt.) were maintained. The oral administration of SPHAG had showed significant reduction in the glucose level and HbA1C level when compared with Disease Control. Biochemical parameters comprising of liver function and renal function tests had shown improved health status in SPHAG treated groups over Disease Control group. The antioxidant enzymes superoxide dismutase, Glutathione peroxidase levels in blood and tissues including liver, kidney and heart were found to be decreased in the Disease control group. SPHAG treated animals showed significant improvement on the antioxidant enzyme levels and the efficacy is found to be dose dependent. Thus, the present study has demonstrated hypoglycaemic and antioxidant potential of SPHAG in the experimental animals. The synergistic contribution of major phyto-constituents of SPHAG i.e. flavonoids and phenols are expected for its biopotency and efficacy.
Page(s) : 767-772
ISSN : 0975-9492
Source : Vol. 6, No.4