ISSN : 0975-9492


Open Access

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Title : In-vivo Self Emulsification: Tools for Bioavailability Enhancement
Authors : Shweta Mishra, Akanksha Bhandari, Pramod Kumar Sharma
Keywords : self-emulsifying drug delivery system, Lipid based formulation, Application, Herbal Formulation, Surfactant.
Issue Date : March 2015
Abstract :
With the advancements in science and technology, a lot of new drug molecules have been added and are being added to our repertoire of drugs for fighting against diseases and ailments that trouble mankind. Each and every drug molecule is different in respect of their physico-chemical properties, thereby differing in their biotherapeutic effects. Problems like poor solubility and low permeability may render a perfectly effective drug molecule inactive in vivo because of low bioavailabilty. Thus the drug molecules which fall under the BCS category of Class II and Class IV represent certain specific problems regarding attainment of therapeutic drug concentrations at the required site and their bioavailability. Various techniques and drug delivery systems are being developed for such drugs. SEDDS or SELF’s represent one of such efforts. SEDDS are an isotropic mixture of one or more hydrophilic solvent and co- solvent /surfactants. On mild agitation they form fine oil –in- water (o/w) microemulsion. This present study aims at studying the various formulation, classification, optimization and utilization aspects of these systems.
Page(s) : 502-511
ISSN : 0975-9492
Source : Vol. 6, No.3