ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Toxicity assessment of ethanol extract of Solanum villosum (Mill) on wistar albino rats.
Authors : Venkatesh R, Kalaivani K, Vidya R
Keywords : Solanum villosum, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), bw body weight, lethal dose.
Issue Date : July 2014
Abstract :
Purpose: To evaluate the potential toxicity of ethanol extract of the medicinal plant Solanum villosum (Mill). Methods: Ethanol extract of S. villosum administered orally at ranges of doses 100, 200, 400, 600 and 800 mg/kg/bw to assess its impact on biochemical indices of Wistar albino rats. Hematological profile, biochemical assays, antioxidant and lipid peroxidation assays were compared between control and experimental animals. An acute toxicity test was performed in rats at different concentration of ethanol extract of S. villosum in order to establish the approximate oral lethal dose (LD) 50. Results: No mortality occurred during the two weeks experimental period, in both control and experimental groups. The changes in biochemical parameters were statistically insignificant at p<0.05 levels. The treated rats showed that very less toxic symptoms only after 800 mg/kg/bw. These observations were supported by hematological and liver function markers. Conclusions: The medicinal plant Solanum villosum can be administered orally at a dose range of 200 mg/kg/bw was very effective and without any side effects. Ethanol extract of S. villosum is not toxic and therefore it may be used safely in clinical trials. It is the first documented report about the plant Solanum villosum (Mill) in the toxicity assessment study.
Page(s) : 406-412
ISSN : 0975-9492
Source : Vol. 5, No.7