ISSN : 0975-9492
CODEN : IJPSQQ





INTERNATIONAL JOURNAL OF PHARMA SCIENCES AND RESEARCH


Open Access

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ABSTRACT

Title : Cardioprotective effect of Kolaviron (Garcinia kola seed extract) in cholesterol-fed rats.
Authors : NWANERI-CHIDOZIE V. O, ANYANWU K. C, ADARAMOYE O.A, EMEROLE E. O
Keywords : Flavonoids, kolaviron, Garcinia kola, cholesterol, coronary heart diseases (CHD).
Issue Date : March 2014
Abstract :
Flavonoids a group of polyphenolic substances are naturally present in vegetables, fruits, seeds and beverages such as tea and wine. Studies have shown that flavonoid intake is inversely correlated with mortality from coronary heart diseases and myocardial infarction. The effect of kolaviron (a flavonoid complex) extracted from Garcinia kola seeds on the organ weights (lungs, kidneys, heart, spleen and liver) of rats administered with cholesterol, five times a week, for eight consecutive weeks was investigated.
The results revealed that cholesterol administration at a dose of 30mg/day for eight consecutive weeks caused a significant increase (p<0.001) in relative heart weights of the cholesterol-fed rats when compared with the control. However, co-treatment with kolaviron at doses 100 and 200mg/kg significantly (p<0.001) reduced the cholesterol induced enlargement of the heart. This is a pointer to the cardioprotective potential of kolaviron; and thus suggests a possible use as a dietary supplement for the prevention and management of coronary heart diseases.
Page(s) : 96-99
ISSN : 0975-9492
Source : Vol. 5, No.3